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In addition to protein-mediated regulatory pathways during the early stages of interactions, microbial small noncoding RNAs (sRNAs) have recently emerged as an additional regulatory layer

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If, after all of these measures have been taken and other correctable causes of the refractoriness have been ruled out, such as low output or dietary lapses during admission, patients do not yet show a resolution of the fluid overload or life-threatening condition, the use of UF techniques must be considered.1,37,42 If the patient is not indicated for these aggressive treatments, palliative measures to ameliorate symptoms should be applied